BIOL60771 15 Semester 1 Postgraduate Taught Level 7 Anil Day Unit coordinator 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 7.5 <ul> <li> The importance and applications of biopharmaceutical and industrial proteins.</li> <li> Bacterial expression systems.</li> <li> Fungal expression systems.</li> <li> Baculovirus-based expression in insect cells.</li> <li> Animal expression systems.</li> <li> Plant and algal expression systems.</li> <li> Vectors for inducible and constitutive expression</li> <li> Compartmentalisation of products in organelles</li> <li> Post-translational processing including folding, secretion and covalent modifications</li> <li> Regulatory issues and equivalence</li> <li> Purification and good manufacturing practice</li> <li> Confirmation of protein size and structure using physical methods</li> <li> Case studies including important steps for commercialisation</li></ul> <ul> <li> The importance and applications of biopharmaceutical and industrial proteins.</li> <li> Bacterial expression systems.</li> <li> Fungal expression systems.</li> <li> Baculovirus-based expression in insect cells.</li> <li> Animal expression systems.</li> <li> Plant and algal expression systems.</li> <li> Vectors for inducible and constitutive expression</li> <li> Compartmentalisation of products in organelles</li> <li> Post-translational processing including folding, secretion and covalent modifications</li> <li> Regulatory issues and equivalence</li> <li> Purification and good manufacturing practise</li> <li> Confirmation of protein size and structure using physical methods</li> <li> Case studies including important steps for commercialisation</li> </ul> <p>To provide an in-depth understanding of biological production systems for biopharmaceutical and industrial proteins</p> <ul> <li> To understand the importance of biopharmaceutical and industrial proteins</li> <li> To understand the different types of biological expression systems used to produce biopharmaceutical and industrial proteins</li> <li> To critically evaluate and compare biological expression systems using, in part, case studies including important biopharmaceutical proteins and vaccine antigens</li> <li> To understand the importance of regulatory aspects in recombinant protein production of commercial products</li> <li> To be able to understand and analyse original results in the primary literature</li> </ul> Analytical skills Students will critically analyse and evaluate data in industry relevant research articles, patents and case studies to compare biological production systems. Innovation/creativity Students will design a production system to manufacture a pharmaceutical protein. Problem solving Students will be involved in an exercise where they play the role of a company director to address the problems associated with manufacturing a pharmaceutical protein. Research Students will conduct dry research to understand industry relevant biologics and expression systems. <p>The module requires knowledge and understanding of biological production systems and the analytical skills required to apply this to manufacture biopharmaceutical and industrial proteins. Attendance at the lectures, private study including critical analysis of the scientific literature to address the problem question in the field of biotechnology. Students will be introduced to the primary scientific literature and guided through the key steps required to understand and interpret the information.</p> 1 Written exam 100% <p>Formative feedback will be provided on an outline written answer in a F2F class discussion.</p> <p style="margin-left:5.7pt;">A first degree in a biology-related discipline or other discipline combined with biology units</p> MSc Biotechnology Enterprise MSc Biotechnology Enterprise PGDT Taught Component Mandatory N <p>Reading Lists specific to each lecture will be provided. Scientific articles can be accessed as electronic copies from the relevant publishers via the John Rylands library.</p><p>Background Reading</p><p>1) Primrose, S. B., Twyman, Richard M., Old, R. W.<br /> Principles of gene manipulation.Edition 6th ed / Sandy Primrose, Richard Twyman, Bob Old.Publisher Oxford : Blackwell Science, 2001.</p><p>2) Lewin, Benjamin.Title Genes VI / Benjamin Lewin, Oxford : Oxford University Press, 1997</p><p>3) Production of Recombinant Proteins: Novel Microbial and Eukaryotic Expression Systems Gerd Gellissen (Editor) Weinheim : Wiley-VCH, 2005</p> Lectures 20 0 130