Body Systems 2

BIOL21272 Body Systems 2 10 Semester 2 Undergraduate Level 2 Elizabeth Sheader Unit coordinator 1 FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 Body Systems 2 outlines the principal functions of the  human systems primarily the gastro-intestinal (GI) and the renal systems, this unit explains how these systems are affected by diseases and outlines the available treatments.    You will learn about: •    The mechanism and regulation of nutrient absorption by the GI tract •    The importance of the kidneys in maintaining body electrolyte and water balance •    Examples of diseases of the GI tract and kidney, which are targets for important therapeutic drugs •    How molecular genetics has enhanced our understanding of transport processes in the intestines and kidneys   Body Systems 2 outlines the principal functions of the  human systems primarily the gastro-intestinal (GI) and the renal systems, this unit explains how these systems are affected by diseases and outlines the available treatments.    You will learn about: •    The mechanism and regulation of nutrient absorption by the GI tract •    The importance of the kidneys in maintaining body electrolyte and water balance •    Examples of diseases of the GI tract and kidney, which are targets for important therapeutic drugs •    How molecular genetics has enhanced our understanding of transport processes in the GI tract and kidneys  <div> </div> •    To study the principal functions of the human systems primarily the gastro-intestinal (GI)  and the renal system •    To learn how these systems are affected by diseases and about the available treatments. Students will gain an understanding of: •    The mechanism and regulation of nutrient absorption by the GI tract •    The importance of the kidneys in maintaining body electrolyte and water balance •    How molecular genetics has enhanced our understanding of transport processes in the GI tract and kidneys •    Examples of diseases of the GI tract and kidney, which are targets for important therapeutic drugs Analytical skills Analysis and interpretation of data in scientific papers which are source material for the second phase of the unit. Oral communication Questions are encouraged during the lectures. Lecturers also actively question the students. Research Directed reading of annotated scientific papers which are source material for the second phase of the unit. Part 1 includes  • Introduction: Principals of epithelial transport & dietary components. • The physiology of the G.I. tract: Digestion and absorption; Control of G.I function; The mechanism and regulation of salivary, gastric and pancreatic secretion; G.I.motility. Management of peptic ulcers and diarrhoea. • Renal physiology: Glomerular filtration; Reabsorption of nutrients and ions; Production of a concentrated urine; Control of extracellular fluid volume & electrolyte balance; Acid-base balance. Mechanisms of action of diuretic drugs. Renal failure.Part 2 includes : • The molecular physiology of iron transport proteins: Ferric reductase, DMT-1, ferroportin, transferrin, the transferrin receptor and hepcidin. • Cystic Fibrosis: The molecular genetics of C.F.; CFTR an anion channel and channel regulator. • Diuretic action and Bartter’s Syndrome: Diuretic selectivity is dependent on drug secretion. Na+ absorption in the kidney tubule (TAL) is impaired in Bartter’s by mutations to five different proteins. • GI tract infections: Causes of and treatments for diarrhoea and peptic ulcers.e-Learning Activities .E-learning MCQs  questions     0 Other 10% 1 Written exam 90% Summative examination 2hr short-note (45%) on campus   Plus one essay question: time limited (45%). eLearning modules multiple-choice questions (10%) •    Feedback will be provided as part of two online multiple-choice assessments on lecture content and of the two assessments associated with the eLearning activities •    A "Question and Answer session" will be held to discuss any student-raised concerns  BIOL21141 Cell Membrane Structure & Function Co-Requisite Recommended BIOL21321 Membrane Excitability: Ion Channels & Transporters in Action Co-Requisite Recommended N For Part 1 of the unit, useful background information will be found in the texts below. For Part 2 of the unit, essential information will be found in lecture specific references, which will be listed in the unit handbook.Recommended Reading1.     Boron, WF & Boulpaep, EL, Medical Physiology: A Cellular and Molecular Approach (3rd edition), Saunders, 2017, Recommended2.     Koeppen BM & Stanton BA, Berne & Levy Physiology (7th edition), Mosby, 2018, Recommended3.     Rang HP, Dale MM, Ritter JM & Flower, R, Rang & Dale’s Pharmacology (9th Edition), Churchill Livingstone, 2020, Recommended  Assessment written exam 2 Lectures 21 0 77