`Omic Technologies & Resources

BIOL21152 `Omic Technologies & Resources 10 Semester 2 Undergraduate Level 2 Sam Griffiths-Jones Unit coordinator School of Biological Sciences School of Medical Sciences Department of Chemical Engineering 1 FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 'Omic Technologies and Resources will introduce a range of molecular biology, genetic engineering and bioinformatic techniques (e.g., gene cloning, engineering alterations in a gene, screening for genes, genome mapping, sequencing and editing projects), and illustrate how these can be, and have been, applied and adapted to answer major questions in the biological sciences and medical genetics. 'Omic Technologies and Resources will introduce a range of molecular biology, genetic engineering and bioinformatic techniques (e.g., gene cloning, engineering alterations in a gene, screening for genes, genome mapping, sequencing and editing projects), and illustrate how these can be, and have been, applied and adapted to answer major questions in the biological sciences and medical genetics.  This unit will introduce a range of molecular biology, genetic engineering and bioinformatic techniques and illustrate how these can be, and have been, applied and adapted to answer major questions in the biological sciences and medical genetics. Using a topical example-driven approach - including human, animal, plant and micro-organismal - students will be exposed to a number of the important techniques that underpin many of the recent advances in understanding biological systems at the molecular level. Examples will be used to explain the step change that occurs between the analysis of single genes, proteins etc. and the analysis of most, or all, of the genes, proteins and metabolites within an organism. In addition, students will gain an understanding of the cross-talk and interactions that occur between different genes and gene products. Upon completion of this unit, students will gain an understanding of:<ul> <li>Gene cloning, engineering alterations in a gene, screening for genes.</li> <li>Genome mapping and sequencing projects.</li> <li>Manipulating DNA in vitro and genomes in vivo.</li> <li>Transcriptomics approaches.</li> <li>How proteins can be made and manipulated.</li> <li>Using single-celled organisms, plants and animals as experimental models.</li> <li>Dealing with large-scale datasets generated from ’omic scale experiments.</li></ul>  Analytical skills Online exercises require students to analyse data and experimental results. Oral communication Students encouraged to answer questions during lectures. Problem solving Online exercises require students to read and research around the lecture material. Research Online exercises require background reading and the understanding of some primary literature. Written communication Students participate in a practice examination-style essay which is marked by staff and detailed comments are returned. <ul> <li>Analysis of individual genes</li> <li>Analysis of genomes (transcriptomics)</li> <li>Understanding gene function (proteomics)</li> <li>Analysis of small molecules (metabolomics)</li> <li>Understanding the integration of the above (systems biology)</li></ul>  0 Other 20% 1 Written exam 80% The written exam is one problem-based question (50% of exam) and one essay from a choice (50% of exam). Weekly online multiple choice exercises make up 20% of the overall mark. Students will receive feedback via the Canvas module for this unit, which forms part of the continuous assessment of the unit. Students will also be afforded the opportunity to receive written feedback on an examination-style essay and a series of examination-style short-answer questions. BIOL10221 Molecular Biology Pre-Requisite Compulsory BIOL21101 Genome Maintenance & Regulation Co-Requisite Recommended BIOL21152 Pre-requisite is BIOL10221BIOL21152 Pre- & Co-requisites are BIOL10221 N <ul> <li>Brown, TA (2017) Genomes (4th edition). Garland Science - recommended</li></ul> Assessment written exam 2 Lectures 22 0 76