BIOL31311 Structural Biology 10 Semester 1 Undergraduate Level 3 Andrew Doig Unit coordinator School of Biological Sciences Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Last part of a Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 <p>Proteins perform a vast array of functions within living organisms. This unit will covering a range of high profile, contemporary topics in Protein Science, from folding and assembly through to dynamics and membrane transport. You will also study how structural studies of macromolecular assemblies are leading to the development of nanodevices.</p> <p>Proteins perform a vast array of functions within living organisms. This unit will covering a range of high profile, contemporary topics in Protein Science, from folding and assembly through to dynamics and membrane transport. You will also study how structural studies of macromolecular assemblies are leading to the development of nanodevices.</p> <p>The unit aims to provide students with an introduction to modern Protein Science, covering a representative range of high profile, contemporary topics, from folding, design and assembly through to dynamics and membrane transport.</p> <p>Knowledge of the way in which proteins fold, assemble, self-polymerise, move and can be observed.</p> Analytical skills Data analysis coursework Problem solving Data analysis coursework Written communication Coursework and data analysis problems <p>A) <strong>Protein Engineering: </strong>Protein stability; techniques used to study protein structure. Protein folding landscapes and pathways. Design of new proteins<br />B) <strong>Protein dynamics: </strong>methods used to study it, including NMR, hydrogen exchange/mass spectrometry and simulations. Role in protein function.<br />C) <strong>Membrane proteins/transporters and receptors</strong>, including methods to probe dynamics such as HDX-MS. Sym and Antiporters. ABC transporters. Ion channels.<br />D) <strong>Macromolecular machines and nanobiotechnology.</strong> How structural studies of macromolecular assemblies are leading to the development of nanodevices.</p> 0 Other 10% 1 Written exam 90% <div>Examination (90%) 2 hours, 2 questions from 5;<br />Other - NMR and EPR problem (10%)</div> <ul> <li>Online discussion.</li> <li>Feedback on data handling problems.</li></ul> BIOL21111 Proteins Pre-Requisite Compulsory BIOL31311 Pre-requisite is BIOL21111<ul> <li> BIOL21111 Proteins (Compulsory)</li> </ul> N <p>Papers will additionally be recommended by individual lecturers.</p><p><strong>Recommended Reading</strong></p><ol> <li> Lesk, AM, Introduction to Protein Science Architecture, Function &amp; Genomics (ISBN 987-0-19-954130), Oxford University Press, 2010, Recommended</li> <li> Petsko, G &amp; Ringe, D, Protein Structure and Function: Primers in Biology (ISBN 978-1-4051-1922-1), Wiley-Blackwell, 2003, Recommended</li> <li> Whitford, D, Proteins: Structure and Function (ISBN: 0-471-49894-7), John Wiley &amp; Sons Ltd, 2005, Recommended</li> <li> Williamson, M, How Proteins Work (ISBN: 0815344465), Taylor &amp; Francis 2011, Recommended</li></ol> Assessment written exam 1.3 Lectures 18 0 80.7