BIOL31441 10 Semester 1 Undergraduate Level 3 Alan Whitmarsh Unit coordinator 1 FHEQ level (Framework for Higher Education Qualifications) ' Last part of a Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 The cells of our body integrate signals from multiple stimuli in order to mount appropriate physiological responses. These signals are transmitted to specific targets within the cell by intracellular signalling pathways that employ post-translational modifications, particularly phosphorylation. The fidelity of signal transmission by these pathways and the cross-talk between them are tightly controlled. This unit will cover how key signalling pathways in cells transduce extracellular signals to regulate gene expression and cellular processes such as growth and apoptosis. It will also provide an understanding of how disruption of these pathways can lead to diseases such as cancer and stroke. The cells of our body integrate signals from multiple stimuli in order to mount appropriate physiological responses. These signals are transmitted to specific targets within the cell by intracellular signalling pathways that employ post-translational modifications, particularly phosphorylation. The fidelity of signal transmission by these pathways and the cross-talk between them are tightly controlled. This unit will cover how key signalling pathways in cells transduce extracellular signals to regulate gene expression and cellular processes such as growth and apoptosis. It will also provide an understanding of how disruption of these pathways can lead to diseases such as cancer and stroke. • provide an understanding of the mechanisms by which cells communicate • illustrate the commonality and differences in these mechanism using examples of key signalling molecules and pathways • provide a basis for understanding disease processes in which signalling is compromised • give insight into the experimental methods used for studying cell signalling Students will be able to: • describe the various types of signalling molecules including receptors, adapter proteins, second messengers, kinases and phosphatases • understand how the physical properties of signalling molecules influence their behaviour • describe the major intracellular signalling pathways in cells and have an understanding of their complexity and the interactions between them • have an understanding of the link between extracellular signals and intracellular events, including the regulation of gene expression and apoptosis • discuss the relevance of cell signalling in a variety of physiological and pathological situations • appreciate the experimental techniques associated with the study of cell signalling • research the scientific literature to enhance their knowledge and develop their critical thinking skills. Group/team working Students participate in a Teams-Based Learning exercise (TBL) where they work in groups to apply their knowledge to problems. Written communication Students write an essay that provides training in logically organising ideas under time pressure. • Introduction to cell signalling: signalling networks, protein-protein interactions, protein phosphorylation/de-phosphorylation. • Receptors: types of receptor (RTK, GPCR, TGF, cytokine and Wnt receptors), their mechanism of action and their regulation. • Second messengers: calcium, cAMP and phospholipid signalling. • Intracellular signalling pathways: covering the major pathways in cells (MAPK, PI3K-AKT, mTOR, JAK-STAT, SMAD, IKK-NF-B, Wnt), their components and key roles of protein kinases and phosphatases. • Transcriptional regulation by signalling pathways: roles of transcription factors and chromatin modifications. • Techniques used to research cell signalling. 0 Other 100% Written exam: 100% Written exam: Part 1 consists of short answer questions and Part 2 is to write an essay. In the TBL sessions, students will receive both individual and group feedback. BIOL21121 The Dynamic Cell Pre-Requisite Recommended BIOL21351 Molecules and Cells in Human Disease Pre-Requisite Recommended BIOL21101 Genome Maintenance & Regulation Pre-Requisite Recommended BIOL21742 Introduction to Cancer Pre-Requisite Recommended N • Lim, W et al (2014) Cell Signaling. Garland Science. • Hancock, J.T. (2005) Cell Signalling (2nd edition). Oxford University Press Assessment written exam 2 Lectures 18 0 80 Dr Gino Poulin, Dr Cathy Tournier, Dr Alan Whitmarsh