Advanced Developmental Biology

BIOL31642 Advanced Developmental Biology 10 Semester 2 Undergraduate Level 3 Andreas Prokop Unit coordinator 1 FHEQ level (Framework for Higher Education Qualifications) ' Last part of a Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 Developmental Biology is a key discipline for the biomedical sciences. On this unit you will gain an understanding of the many biomedically relevant concepts born out of this discipline and their important contributions to modern medical applications. For further information see: <a href="http://bsdb.org/advocacy">bsdb.org/advocacy</a>.  You will gain an understanding of the molecular and cellular mechanisms which lead to the proper development of limbs, head structures and internal organs, of how these mechanisms are re-used during regeneration and how they link to disease. This course is ideal also for anatomy students, introducing them to the mechanistic concepts underlying embryo development.  The aim of this course is to understand concepts and mechanisms of Developmental Biology, comparing and contrasting them between limbs and their various tissues, head structures and internal organs. Through this, students will learn about the fundamental processes leading to developmental disorders and disease, and the crucial roles that Developmental Biology has played and continues to play in generating key concepts for medical application including stem cells, signalling networks, cancer or wound healing.   Students will gain basic knowledge and understanding of:•   how a single fertilised egg cell develops gradually into a complex, three-dimensional, multicellular organism composed of highly organised tissues, such as bone, cartilage, skin, muscles, nervous system, blood and blood vessels, internal organs or head structures.•   how fundamental molecular and cellular mechanisms (e.g. differential gene expression, cytoskeletal dynamics or endocytic trafficking), cell communication (e.g. signalling, adhesion) and developmental concepts (asymmetric cell division, pattern formation, cell migration, branching) contribute during these processes.•   how these different mechanisms integrate at the level of whole tissues, organs and organisms, and how they are functionally adapted in distinct developmental contexts.•   how studying these mechanisms provides important understanding of developmental human disorders, such as mental retardation, spina bifida or malformations, but also processes underlying neurodegeneration, cancer or wound healing.  Analytical skills Recognising commonalities and differences of molecular and cellular mechanism in different contexts Innovation/creativity Modern trends in Biology and their various uses and applications; creative thinking about biological problems in ways different from any current text books Problem solving Addressing course materials from different angles, as practiced in e-assessments and the essay outline exercise Research Understanding of research strategies and the appreciation of molecular and cellular mechanisms at the level of tissues and organisms - immediately relevant for patho-mechanisms underpinning disease Written communication Principles of essay writing Other Principle skills of data presentation; applying concepts of developmental biology to human embryology or regenerative medicine Developmental Biology is a key discipline in the biomedical sciences with unparalleled impact on medical applications and concepts (see: bsdb.org/advocacy). Developmental Biology asks fundamental, conceptual questions at the level of organisms, tissues or organs and operates therefore at the level at which diseases become manifest. Consequently, Developmental Biology has to integrate knowledge and research strategies across the different levels of understanding, which makes it an intellectually rewarding discipline that has given us concepts including cell signalling, cell division, stem cells, cell adhesion, cell migration - all being fundamental to the understanding of diseases and conditions such as cancer, wound healing, birth defects, developmental brain disorders as well as regeneration, ageing or neurodegeneration.For this lecture course, we developed a new way of teaching Developmental Biology by posing fundamental questions about body development and then explain the current knowledge that can deliver satisfactory answers. In this way, the course is an ideal combination of classical embryology and modern Developmental Biology. The first half of this lecture series will ask the fundamental question of how limbs are formed, thus introducing to the underlying patterning mechanisms and fundamental developmental processes of all tissues involved. We will then ask about additional developmental strategies required to make specialisations of the head or inner organs and address the point as to whether these developmental mechanisms are re-used during tissue regeneration.•  Part 1: How to make a limb? An integrated view: How does a limb bud know where to form? How are the axes of the limb determined? How does the limb acquire its appropriate size? How do skin and its appendages, skeletal muscles, skeleton, blood cells and vessels, nerves and functional synaptic contacts form?•  Part 2: How to make a head? How do head-specific features, such as head skeleton, ears and teeth develop? How does this compare to principles learned from limb development?•  Part 3: How to make internal organs? How do tubular organs, such as lung and kidney, form or glandular organs including pancreas, mammary and salivary glands? Does the development of internal organs differ from peripheral structures?•  Part 4: Are mechanisms of development re-employed during regeneration? A brief overview of the biology of regeneration.  1 Written exam 70% 7 Oral assessment/presentation 30% 30% for a recorded group presentation (groups of 3-4) of an essay question, starting with a bullet point outline followed by a more detailed elaboration on the content. Recordings will be marked and made available to other students.70% for a single essay out of 5 questions written as on-site exam  <ul><li>Feedback on 3 formative multiple-choice/answer e-assessments </li><li>Written feedback on the presentation recordings    </li></ul> BIOL21172 Principles of Developmental Biology Pre-Requisite Recommended N •  Gilbert, SF and Barrish MJ (2020) Developmental Biology (12th edition). Sinauer.• Wolpert, L and Tickle, C (2019) Principles of Developmental Biology (6th edition). Oxford University Press.• Martinez Arias A and Stewart A (2002) Molecular Principles of Anim Assessment written exam 1 Lectures 18 0 81