Haematological Malignancies 2

BIOL66521 Haematological Malignancies 2 15 Semester 1 Postgraduate Taught Level 7 Paul Shore Unit coordinator 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 7.5 This unit builds on the concepts and approaches identified in the haematological malignancies 1 module by investigating more complex and heterogeneous haematological neoplasms including AML, ALL, MDS and B-CLL as exemplars. Trainees will appreciate the importance of the role of molecular genetics approaches for the correct classification of heterogeneous disorders such as AML and Diffuse large B-cell lymphoma (DLBCL). Trainees will also gain knowledge of other haematological malignancies such as myeloma and less common lymphoid malignancies.   This unit builds on the concepts and approaches identified in the haematological malignancies 1 module by investigating more complex and heterogeneous haematological neoplasms including AML, ALL, MDS and B-CLL as exemplars. Trainees will appreciate the importance of the role of molecular genetics approaches for the correct classification of heterogeneous disorders such as AML and Diffuse large B-cell lymphoma (DLBCL). Trainees will also gain knowledge of other haematological malignancies such as myeloma and less common lymphoid malignancies. This unit provides trainees with an in-depth knowledge of the diagnosis, prognosis and molecular monitoring of patients with a range of complex haematological malignancies.  Students will be able to:  <ul><li>Describe the underlying pathogenesis of acute myeloid leukaemia(AML), acute lymphoblastic leukaemia (ALL),  chronic lymphocytic lymphoma (B-CLL) and myelodysplastic syndromes (MDS).</li><li>Classify heterogeneous myeloid and lymphoid malignancies using international guidelines.</li><li>Evaluate the role of molecular genetic analysis for sub-classification of disorders.</li><li>Determine the laboratory approaches for the diagnosis, classification, and prognosis of acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) chronic lymphocytic lymphoma (B-CLL) and myelodysplastic syndromes (MDS).</li><li>Summarise the clinical management and treatment approaches applicable to acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic lymphocytic lymphoma (B-CLL) and myelodysplastic syndromes (MDS).</li><li>Critically Evaluate the methods available for monitoring of residual disease including molecular genetic approaches and multi-parametric flow cytometry, selecting the most appropriate technique for each disorder. </li></ul> Students will be able to:  <ul><li>Apply acquired knowledge to area of own healthcare practice to interpret and evaluate information regarding laboratory test results for patients with haematological malignancies.</li><li>Interpret scientific data and summarise the key findings.</li><li>Critically evaluate the scientific evidence supporting our understanding of haematological malignancies.</li></ul> Students will be able to:  <ul><li>Retrieve, manage and collate information from primary and secondary sources.</li><li>Present information clearly in the form of verbal and written reports.</li><li>Communicate complex ideas and arguments in a clear and concise and effective manner.</li><li>Work effectively as an individual or part of a team. </li></ul> Students will be able to:  <ul><li>Demonstrate capacity for self-learning and independent thinking and to utilise problem solving skills.</li><li>Critically evaluate their personal performance both as an individual and within a team.</li><li>Demonstrate skills in working collegiately and effectively with others as a member of a team; evaluating others performance in a positive and enriching manner.</li><li>Be able to set priorities and link these with effective time management.</li><li>Effectively utilise a range of information sources.  </li><li>Interpret data and convert into knowledge for use in the clinical context of individual and groups of patients.  </li></ul> In this unit, we have adopted a flipped instructional model, leveraging technology to provide a flexible learning experience with active participation in both asynchronous and synchronous activities.  The content will be delivered using a variety of materials and modes to engage learners including, audio, video, reading, data analysis, application exercises, formative MCQs, discussion boards. These resources offer students the flexibility to engage with the material at their own pace and convenience.Complementing the asynchronous content, students will participate in live online events designed to enhance interaction and deepen understanding. These events include Team-Based Learning (TBL) sessions, question and answer sessions (Q&A), and select live lectures.Through this hybrid approach, students benefit from the best of both worlds: self-directed learning opportunities with asynchronous content and collaborative engagement during live sessions. This dynamic combination fosters active participation, encourages critical thinking, and promotes a comprehensive understanding of the course material.  0 Other 40% 2 Written assignment (inc essay) 60% 1 hour MCQs 40%1x Written assessment 2,000 words 60% Immediate feedback on MCQs will be provided during the live events.Written feedback on the written assignment will be provided in 15 working days. N Weinberg, R.A., The Biology of Cancer. New York: Garland Science, Taylor & Francis Group, 2014.  Haojian, Z. and L. Shaoguang. Leukemia Stem Cells in Hematologic Malignancies. Springer Singapore, 2019. (ISBNs 978-9-81-137341-1, 978-9-81-137342-8)  Lectures 8 0 142