Instrumental Analytical Chemistry

CHEM40211 Instrumental Analytical Chemistry 10 Semester 1 Undergraduate Level 4 Nicholas Lockyer Unit coordinator Royston Goodacre Unit coordinator Adam McMahon Unit coordinator Perdita Barran Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 5.0 Workshops and practical demonstrations will be integrated into the lecture schedule below:            Advanced Separation Science (Prof Perdita Barran, 6 h)<ul> <li> Advanced column chromatography</li> <li> Analytical ultracentrifugation</li> <li> Microfluidics and lab-on-a-chip</li> <li> Coupling column chromatography to mass spectrometry</li> <li> Ion Mobility</li></ul>Advanced Mass Spectrometry (Dr Nick Lockyer, 5 h)<ul> <li> Mass spectrometer design and operation</li> <li> Solid phase ion sources for mass spectrometry</li></ul>Molecular Imaging (Dr Nick Lockyer and Dr Adam McMahon, 5 h)<ul> <li> Mass spectrometry imaging</li> <li> Positron Emission Tomography</li></ul>Practical considerations of vibrational spectroscopic analysis (Prof Roy Goodacre – 8 h)<ul> <li> Raman spectroscopy and sampling.</li> <li> Introduction to biological analysis and food adulteration.</li> <li> SERS for the detection of biomaterials.</li> <li> Raman spectroscopy for the analysis of bacteria.</li> <li> Chemical imaging.</li> <li> Forensics and Raman spectroscopy workshop: identification of ‘white powders’ found at crime scenes</li></ul> Workshops and practical demonstrations will be integrated into the lecture schedule below:            Advanced Separation Science (Prof Perdita Barran, 6 h)<ul> <li> Advanced column chromatography</li> <li> Analytical ultracentrifugation</li> <li> Microfluidics and lab-on-a-chip</li> <li> Coupling column chromatography to mass spectrometry</li> <li> Ion Mobility</li></ul>Advanced Mass Spectrometry (Dr Nick Lockyer, 5 h)<ul> <li> Mass spectrometer design and operation</li> <li> Solid phase ion sources for mass spectrometry</li></ul>Molecular Imaging (Dr Nick Lockyer and Dr Adam McMahon, 5 h)<ul> <li> Mass spectrometry imaging</li> <li> Positron Emission Tomography</li></ul>Practical considerations of vibrational spectroscopic analysis (Prof Roy Goodacre – 8 h)<ul> <li> Raman spectroscopy and sampling.</li> <li> Introduction to biological analysis and food adulteration.</li> <li> SERS for the detection of biomaterials.</li> <li> Raman spectroscopy for the analysis of bacteria.</li> <li> Chemical imaging.</li> <li> Forensics and Raman spectroscopy workshop: identification of ‘white powders’ found at crime scenes</li></ul> In this unit you will learn about the theory, design and application of advanced analytical instrumentation.  The material builds on your understanding of techniques including mass spectrometry and molecular spectroscopy leading to an appreciation of the start-of-the art technologies and methods that underpin much of modern research in chemistry, biology, materials science etc.  After completing the course unit, participants should be able to:<ul> <li> Reflect on the challenges in determining complex multi-component systems and fast chemical kinetic processes.</li> <li> Describe the principles of advanced separation science, mass spectrometry and spectroscopy techniques to obtain experimental measurements in the most challenging analytical tasks.</li> <li> Explain and justify the configuration and design principles of advanced instrumentation for the above techniques.</li> <li> Appreciate the range of analytical applications of the techniques.</li> <li> Argue the strengths and limitations of the above techniques and how they can be used in combination to meet analytical challenges.</li> <li> Create appropriate analytical strategies for a variety of chemical and biological problems.</li></ul> <ul> <li> Numeracy and problem solving – applying knowledge of analytical techniques to solve problems</li> <li> Communication skills- presenting scientific material and arguments clearly and correctly in writing and orally during workshops</li> <li> Evaluation and decision making – selecting appropriate analytical instrumentation and strategies</li> <li> Independent learning – time-management and organisation skills</li></ul> 1 Written exam 100% <ul> <li> Feedback will be available in the workshop sessions and/or practical demonstrations.</li> <li> Past exam questions will be addressed in workshops and all lecturers are available to discuss subject matter with students throughout the course.</li></ul> N <ul> <li> Chemical Instrumentation, R P Wayne, OUP, 1994.</li> <li> Chemical Sensors, R.W. Cattrall, OUP Primer series, 1997.</li> <li> Mass Spectrometry: Principles and Applications, E. de Hoffman, J. Charette and V. Stroobant (Wiley).</li> <li> Encyclopedia of Applied Spectroscopy, D.L. Andrews (ed.), Wiley-VCH, Weinheim, 2009</li></ul> Assessment written exam 2 Lectures 18 Practical classes & workshops 6 0 74