Core Organic Chemistry C

CHEM40442 Core Organic Chemistry C 10 Semester 2 Undergraduate Level 3 Andrew Doig Unit coordinator Roger Whitehead Unit coordinator Daniele Leonori Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 5.0 Biosynthetic Pathways (Professor Sabine Flitsch, 8 lectures)<ul> <li> Introduction to Biosynthesis and Metabolism</li> <li> Enzymes, Catalysis and Cofactors</li> <li> Reactions of the Glycolysis Pathway</li> <li> Reactions of the Citric Acid Cycle</li></ul> Reactive Intermediates (Dr Roger Whitehead, 8 lectures)<ul> <li> Introduction to Reactive Intermediates</li> <li> What are radicals, carbenes, nitrenes, arynes?</li> <li> Carbon-centred radicals structure and generation</li> <li> Traditional and modern synthetic applications of carbon-centred radicals</li></ul> Polymer Chemistry (Professor  Mike  Turner, 8 lectures)<ul> <li> Types of polymers, names and sources</li> <li> Introduction to step-growth and chain-growth polymerisation mechanisms, including ionic, radical and ring-opening polymerisation.</li> <li> How to control polymer form, molecular weight and backbone architecture.</li> <li> The structures of common commercial polymers will be introduced.</li></ul>   Biosynthetic Pathways (Professor Sabine Flitsch, 8 lectures)<ul> <li> Introduction to Biosynthesis and Metabolism</li> <li> Enzymes, Catalysis and Cofactors</li> <li> Reactions of the Glycolysis Pathway</li> <li> Reactions of the Citric Acid Cycle</li></ul> Reactive Intermediates (Dr Roger Whitehead, 8 lectures)<ul> <li> Introduction to Reactive Intermediates</li> <li> What are radicals, carbenes, nitrenes, arynes?</li> <li> Carbon-centred radicals structure and generation</li> <li> Traditional and modern synthetic applications of carbon-centred radicals</li></ul> Polymer Chemistry (Professor  Mike  Turner, 8 lectures)<ul> <li> Types of polymers, names and sources</li> <li> Introduction to step-growth and chain-growth polymerisation mechanisms, including ionic, radical and ring-opening polymerisation.</li> <li> How to control polymer form, molecular weight and backbone architecture.</li> <li> The structures of common commercial polymers will be introduced.</li></ul>  Develop further understanding of synthetic, mechanistic organic, polymer and bioorganic chemistry with emphasis on polymer synthesis, reactive intermediates and biosynthetic pathways  Students successfully completing this unit should have developed the ability to:·         describe and explain the fundamentals of metabolism in terms of reaction mechanisms and the action of cofactors;·         explain the detailed mechanisms of glycolysis and the citric acid cycle using mechanistic and physical organic arguments;·         deconstruct unseen problems in biosynthesis and rationalise the component steps in metabolic terms;·         describe the various types of reactive intermediates that are of importance in organic chemistry and explain the physical properties and chemical reactivity of such species;·         describe the factors that influence the structure, stability and reactivity of different radical species and explain the outcome of important reaction processes;·         describe the various reaction types undergone by synthetically useful free radicals;·         predict and rationalise the outcome of unseen transformations involving reactive intermediates;·         describe the main types of polymers by their structure, composition, names and sources;·         explain the detailed mechanisms of step growth and chain growth polymerisation and predict the expected degree of polymerisation for common examples;·         describe how control over polymer form, molecular weight, architecture and microstructure of the polymer backbone is exerted·         propose and rationalise suitable polymerisation processes given a starting monomer or desired polymer structure. Enhance transferable skills in the areas of problem solving and analysis 1 Written exam 100% In-lecture and between-lecture problems, core tutorials and individual feedback from tutors/lecturers CHEM30411 Core Chemistry 1 Pre-Requisite Compulsory N ·         J McMurry, T Begley, The Organic Chemistry of Biological Pathways, Roberts and Co.·         J Staunton, Primary Metabolism - A Mechanistic Approach, Clarendon Press·         J P Clayden, N Greeves, S Warren and P L Wothers, Organic Chemistry, OUP, 2000·         C J Moody, G H Whitham, Reactive Intermediates (An Oxford Chemistry Primer)·         A F Parsons, An Introduction to Free Radical Chemistry, Blackwell Science·         R.J. Young and P.A. Lovell, Introduction to Polymers, 3rd Edn., 2011, CRC Press·         M.P. Stevens, Polymer Chemistry – An Introduction, 3rd Edn., 1999, OUP Assessment written exam 2.5 Lectures 24 Tutorials 3 0 70.5