MSc Core Chemistry 1

CHEM60411 MSc Core Chemistry 1 15 Semester 1 Postgraduate Taught Level 6 Nathan Owston Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 7.5 The unit aims to develop further understanding of mechanistic organic chemistry with a specific emphasis on i) stereoselective reactions; ii) reactive intermediates and iii) pericyclic processes. Elements of strategy, control and application to the synthesis of complex molecules are exemplified throughout the unit.   The unit aims to develop further understanding of mechanistic organic chemistry with a specific emphasis on i) stereoselective reactions; ii) reactive intermediates and iii) pericyclic processes. Elements of strategy, control and application to the synthesis of complex molecules are exemplified throughout the unit.   The unit aims to develop further understanding of synthetic and mechanistic organic chemistry introduced in the previous years.  On successful completion of the course students should be able to: • Apply knowledge of molecular structure, reactivity and stereochemistry to both rationalise and predict the stereochemical outcome of chemical reactions. • Evaluate and propose strategies for the synthesis of complex molecules which include stereoselective reactions. • Describe the various types of reactive intermediates that are of importance in organic chemistry and explain the physical properties and chemical reactivity of such species. • Describe the factors that influence the structure, stability and reactivity of different radical species and explain the outcome of important reaction processes. • Describe the various reaction types undergone by synthetically useful free radicals. • Predict and rationalise the outcome of unseen transformations involving reactive intermediates • Apply knowledge of molecular orbital theory and stereochemistry to both rationalise and predict the outcome of pericyclic reactions.  Problem solving and analysis; academic writing Stereoselective Synthesis (Prof. Guillaume De Bo, 7 sessions) 1-3. Stereoselective synthesis in cyclic systems4-6. Stereoselective synthesis in acyclic systems7. Asymmetric synthesis    Reactive Intermediates (Dr Carl Poree, 7 sessions) 1. Introduction to reactive intermediates2. Arynes and strained alkynes.3. Carbenes, carbenoids and nitrenes.4-7. Radicals Pericyclic Reactions (Dr Nathan Owston, 7 sessions)   1. Introduction to pericyclic reactions2-3. Cycloadditions  4-5. Electrocyclic Reactions6-7. Sigmatropic Rearrangements  1 Written exam 100% <span class="NormalTextRun SCXW21368877 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:14.6667px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:none;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;padding:0px;text-align:left;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:pre-wrap;widows:2;word-spacing:0px;">Feedback information is present on the Course’s Blackboard Page.<span class="NormalTextRun SCXW21368877 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:14.6667px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:none;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;padding:0px;text-align:left;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:pre-wrap;widows:2;word-spacing:0px;">CHEM60411 is delivered in a way which allows students to regularly receive feedback on their work and progress in synchronous sessions. This is achieved through a significant amount of content being delivered as worked examples/content/problems during sessions. Such delivery allows provision of formative feedback through material, comments and suggestions which are designed to help guide students in their own conceptualization and approach to solving problems.  Worked content and problems offer opportunities for both facilitator and peer feedback by -    Providing opportunities for students to master concepts introduced in lectures, and apply these concepts to unseen material. -    Encouraging development of thinking skills (with a focus on critical thinking, analysis, evaluation and application, rather than simple reproduction of knowledge/process) -    Promoting teamwork and collaboration, and the development of skills associated with this, as well as individual responsibility for learning. -    Providing time for students to reflect upon their own learning, and to self-evaluate. In addition, facilitators share problem-solving approaches/common misconceptions through whole-class feedback.Workshop sessions Provide an opportunity to deliver assessment-specific feedback relating to assessment criteria and understanding of question demand, as well as concerning problem solving in examinations (using past paper questions as exemplars). Staff Individual lecturers provide office hours or operate an open-door policy to provide individual, personalised feedback.  <span class="TextRun SCXW116487253 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-style:normal;font-variant-caps:normal;font-variant-ligatures:none !important;font-weight:400;letter-spacing:normal;line-height:17.2667px;margin:0px;orphans:2;padding:0px;text-align:left;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:pre-wrap;widows:2;word-spacing:0px;" data-contrast="auto" xml:lang="EN-GB" lang="EN-GB">Pre-requisite units: Year 1 and Year 2 Core Chemistry  • J. Clayden, N. Greeves, S. Warren and P. Wothers, Organic Chemistry (OUP, 2001) ISBN: 0198503466   • J. Clayden, N. Greeves and S. Warren, Organic Chemistry 2nd edition (OUP, 2012) ISBN: 0199270295 • G. Procter, Stereoselectivity in Organic Synthesis (OUP, 1998) ISBN: 0198559573. • C.J.Moody and G.H.Whitham, Reactive Intermediates (OUP) ISBN: 0198556725. • A.F.Parsons, An Introduction to Free Radical Chemistry (Wiley-Blackwell, 2000) ISBN: 0632052929 • I. Fleming, Pericyclic Reactions (Oxford Chemistry Primer, 2nd Edition) (Oxford University Press, 2015)  ISBN: 0199680900 • I. Fleming, Molecular Orbitals and Organic Chemical Reactions: Student Edition (Wiley-Blackwell, 2009) ISBN: 0470746599 • Access to a set of Orbit molecular models is recommended.  Assessment written exam 2 Lectures 11 Practical classes & workshops 11 Project supervision 16 0 0