Medicines for major health challenges

CHEM20442 Medicines for major health challenges 10 Semester 2 Undergraduate Level 2 John Gardiner Unit coordinator Richard Bryce Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 Lectures by staff from the Division of Pharmacy and Optometry and the Department of Chemistry will discuss: Part 1 Core Concepts for drug molecules (4 lectures)Drug discovery pathway, physiochemical properties and interactions of medicines, Lipinski’s rules, formulation of medicines Part 2 Disease, molecular targets and therapeutics (12 lectures, 4 workshops):Heart failure (2 lectures, 1 workshop), Anti-bacterials (2 lectures, 1 workshop), Cancer (2 lectures, 1 workshop), Brain issues (3 lectures) and Anti-virals (3 lectures, 1 workshop)  Lectures by staff from the Division of Pharmacy and Optometry and the Department of Chemistry will discuss: Part 1 Core Concepts for drug molecules (4 lectures)Drug discovery pathway, physiochemical properties and interactions of medicines, Lipinski’s rules, formulation of medicines Part 2 Disease, molecular targets and therapeutics (12 lectures, 4 workshops):Heart failure (2 lectures, 1 workshop), Anti-bacterials (2 lectures, 1 workshop), Cancer (2 lectures, 1 workshop), Brain issues (3 lectures) and Anti-virals (3 lectures, 1 workshop)  The unit aims to: 1. Provide an introduction to key medicinal chemistry concepts, and to major diseases and how they are treated.  2. Discuss the use of antibacterials to treat Gram positive and negative infections3. Discuss the use of antivirals for the treatment of HIV, HSV and influenza  4. Study the biology of cancer and its treatment  5. Understand the causes and treatment of heart disease  6. Discuss the mechanism of medicines that target the central nervous system  On successful completion of the course students should be able to:   ILO1 Discuss the major diseases and how they are treated.ILO1.1 Explain the use of antibacterial drugs to treat bacterial illnessesILO1.2 Explain the use of antiviral drugs to treat HIV and other viral illnesses;  ILO1.3 Explain the use of anticancer drugs and the underlying biology of cancer;  ILO1.4 Describe the causes, prevention and treatment of cardiovascular disease;  ILO1.5 Describe the treatment of neurological diseases.ILO2 Match a disease with treatment and/or prevention.ILO3 Critically evaluate and apply the principles of the course to specific problems in medicinal chemistry   <div class="OutlineElement Ltr SCXW78021041 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;"><p class="Paragraph SCXW78021041 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-color:transparent;border-left:0.666667px solid rgb(0, 0, 0);border-right:0.666667px solid rgb(0, 0, 0);border-top:0.666667px solid rgb(0, 0, 0);color:windowtext;font-kerning:none;font-style:normal;font-weight:normal;margin:2px 0px 0px;overflow-wrap:break-word;padding:1.33333px 8px 1.33333px 5.33333px;text-align:left;text-indent:0px;user-select:text;vertical-align:baseline;white-space:pre-wrap;" data-ccp-border-bottom="0.6666666666666666px solid #000000" data-ccp-padding-bottom="1.3333333333333333px" paraid="2104186604" paraeid="{f3b95718-cff4-4798-b306-409a67c3fd7d}{211}"><span class="TextRun SCXW78021041 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:MicrosoftSansSerif, MicrosoftSansSerif_EmbeddedFont, sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:17px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-US" lang="EN-US">16 lectures; 4 workshops; coursework via group presentations: Each group of 4-5 students will be assigned a drug relevant to one of the topics above.  Prepare a presentation of 20 minutes (+5 minutes questions) to cover the therapeutic area (include prevalence), drug discovery, drug structure (include functional groups, stereochemistry, conformation, <span class="TextRun SCXW78021041 BCX8 NormalTextRun SpellingErrorV2Themed" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-image:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI1IiBoZWlnaHQ9IjQiPjxnIGZpbGw9Im5vbmUiIGZpbGwtcnVsZT0iZXZlbm9kZCI+PHBhdGggc3Ryb2tlPSIjRTM3RDgxIiBkPSJNMCAzYzEuMjUgMCAxLjI1LTIgMi41LTJTMy43NSAzIDUgMyIvPjxwYXRoIGQ9Ik0wIDBoNXY0SDB6Ii8+PC9nPjwvc3ZnPg==");background-position:0px 100%;background-repeat:repeat-x;border-bottom:1px solid transparent;font-family:MicrosoftSansSerif, MicrosoftSansSerif_EmbeddedFont, sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:17px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-US" lang="EN-US">ionisation<span class="TextRun SCXW78021041 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:MicrosoftSansSerif, MicrosoftSansSerif_EmbeddedFont, sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:17px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-US" lang="EN-US">/<span class="TextRun SCXW78021041 BCX8 NormalTextRun SpellingErrorV2Themed" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-image:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI1IiBoZWlnaHQ9IjQiPjxnIGZpbGw9Im5vbmUiIGZpbGwtcnVsZT0iZXZlbm9kZCI+PHBhdGggc3Ryb2tlPSIjRTM3RDgxIiBkPSJNMCAzYzEuMjUgMCAxLjI1LTIgMi41LTJTMy43NSAzIDUgMyIvPjxwYXRoIGQ9Ik0wIDBoNXY0SDB6Ii8+PC9nPjwvc3ZnPg==");background-position:0px 100%;background-repeat:repeat-x;border-bottom:1px solid transparent;font-family:MicrosoftSansSerif, MicrosoftSansSerif_Embedded Students will understand the mechanism of action of several categories of antiviral agents.Students will be able to match a disease with treatment and/or prevention  <ul><li> Concept assimilation</li><li>Problem-solving skills</li><li>Organizational skills</li><li>Ethical behaviour </li></ul> PART 1. CORE CONCEPTS FOR DRUG MOLECULES Drug discovery pathway (Sam Butterworth, 1h)pKa, and logP relevant to drugs (Andrew Leach, 1h)Bonding relevant to drugs and Lipinski’s rules (Richard Bryce, 1h)Formulation of drugs (Enas Al-Ani, 1h) PART 2. DISEASE, MOLECULAR TARGETS AND THERAPEUTICS i. HEART FAILUREHeart Failure (biology and therapeutics) (Hala Shokr, 1h)Cardiovascular therapeutics (Andrew Leach, 1h)Workshop (Andrew Leach and/or Hala Shokr, 1h)ii. ANTI-BACTERIALSBacterial infections-beta-lactam antibiotics (Richard Bryce, 1h)Bacterial infections-other antibiotics (Richard Bryce, 1h)Workshop (Richard Bryce, 1h)iii. CANCERCancer (Katie Finegan, 1h)Anti-cancer drugs (Sam Butterworth, 1h)Workshop (Katie Finegan / Sam Butterworth, 1h)iv. BRAIN ISSUESDepression (Andrew Leach, 1h)Parkinsons (Sam Butterworth, 1h)Meningitis/CNS tumour/CNS drug discovery (Andrew Leach, 1h)v. ANTI-VIRALSAnti-viral drugs (John Gardiner, 3h lectures + 1h workshop) COURSEWORK (20%)Group presentations (2x 2h)  0 Other 80% 7 Oral assessment/presentation 20% Group Presentation, 20 minutes - 15%Questions on above presentation, 10 minutes - 5%Examination Online (Closed Book) 1.5 hrs - 80% Feedback is given following the workshop verbally.  Detailed individual feedback is given following the course test using Smallvoice.  CHEM10712 Biological Chemistry Pre-Requisite Compulsory N Assessment written exam 2 Lectures 19 Practical classes & workshops 2 0 77 This course is only available to students on the BSc/MChem Chemistry with Medicinal programme.