CHEM20722 10 Semester 2 Undergraduate Level 2 David Leys Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 <p>The unit is delivered by Profs David Leys, Sam Hay and Dr Neil Dixon. Each of the three elements of the course consists of 6-7 lectures and 1 to 2 workshops, and is assessed by exam + course work element</p> <p>The unit is delivered by Profs David Leys, Sam Hay and Dr Neil Dixon. Each of the three elements of the course consists of 6-7 lectures and 1 to 2 workshops, and is assessed by exam + course work element</p> <p>The unit aims to look at protein structure and function relationship in detail, with a focus on looking at proteins relevant to the chemistry (ie mainly enzymes) and consisting of three elements: protein 3D structure determination, protein modelling studies and protein:ligand interactions. The latter aims to look at the importance of non-covalent interactions in chemical and biological systems, and describe some applications in modern chemical research.</p> <p>An understanding of the general properties of the 4 main classes of biomolecules, their general 3D structural features and how this relates to their biochemical function. A clear appreciation of the complexity of biomolecules and the emergent properties that arise from the modular design that underpins them. An ability to visualise protein:ligand complexes and correlate structure features with solution properties. This will provide you with a foundation for the further study of complex biochemical processes, biotechnological application/green chemistry and synthetic biology.</p> <p>Problem solving skills, data mining. modelling and visualisation of complex molecular structures; communication skills</p> <p>Prof David Leys (8 lectures + 4 workshops on macromolecular 3D visualisation)</p><p>2 lectures as Recap on Aqueous chemistry and non-covalent bonding in biology: Hydrogen bonding; Van der Waals; Ionic bonding; Hydrophobic effect; pH/pKa. Protein structure and function: amino acids; primary/secondary/tertiary/quaternary structure, folds and folding, denaturation and stability, dynamic behaviour; advanced concepts in ligand binding</p><p>6 lectures on advanced concepts in protein structure determination/modelling/protein ligand binding + workshop</p><p>Dr Neil Dixon (6 lectures)</p><p>Advanced molecular biology, Nucleotides, inherent properties and reactivity. DNA and RNA covalent and 3D structure. DNA structure – double helices, Hoogsteen base pairing. Triple helices. Base stacking. RNA structure.</p><p>Dr Sam Hay (6 lectures + workshop on mechanism/kinetic models) Advanced Biological catalysis: Enzymes introduction: Active sites.</p> 1 Written exam 80% 2 Written assignment (inc essay) 20% <p>Feedback mechanisms will include direct interactions with students in the lectures as well as in the workshops. Lecturers will make themselves available via office hours or via email.</p> CHEM10712 Biological Chemistry Pre-Requisite Compulsory N <div><p>The recommended text for this course is Voet &amp; Voet Biochemistry, 4th Edition, Wiley. Earlier editions of this text also contain the relevant content.</p></div><p>&nbsp;</p> Assessment written exam 2 Lectures 23 0 75