Personalised Learning Unit 2

CHEM30112 Personalised Learning Unit 2 10 Semester 2 Undergraduate Level 3 Andrew Regan Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Last part of a Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 This personalised learning unit allows students to choose three (CHEM30112) or four (CHEM60112) advanced chemistry topics.  The over-arching aim of the personalised learning unit is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics, to provide a wider and deeper understanding of particular areas of chemistry. The key aims of each of the topics are: Contemporary f-Element Chemistry (D. Mills) – This topic introduces students to the use of molecular design to achieve landmark advances in non-aqueous f-element synthetic chemistry. Catalytic Asymmetric Synthesis (A. Trowbridge) – This topic introduces students to the catalytic processes that are routinely used for the stereoselective synthesis of target molecules.   New topic to be confirmed  (J. Abbenseth) –   Main Group Reagents in Synthesis (A.C. Regan) – This topic introduces students to the use of silicon-, sulfur- selenium- and phosphorus-containing reagents in organic synthesis. Metal-Organic Frameworks (Y. Ma) - This topic introduces students to porous metal-organic framework materials. Chemical Concepts from Quantum Mechanics (P. Popelier) – This topic introduces students to Quantum Chemical Topology, the most comprehensive and coherent way of extracting chemical insight from modern wavefunctions.The course will also introduce research-level topics in this area.  <div style="border:1.0pt solid windowtext;mso-border-alt:solid windowtext .5pt;mso-element:para-border-div;padding:1.0pt 6.0pt 1.0pt 4.0pt;">This personalised learning unit allows students to choose three (CHEM30112) or four (CHEM60112) advanced chemistry topics.   This personalised learning unit allows students to choose three (CHEM30112) or four (CHEM60112) advanced chemistry topics.  The over-arching aim of the personalised learning unit is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics, to provide a wider and deeper understanding of particular areas of chemistry. The key aims of each of the topics are: Contemporary f-Element Chemistry (D. Mills) – This topic introduces students to the use of molecular design to achieve landmark advances in non-aqueous f-element synthetic chemistry. Catalytic Asymmetric Synthesis (A. Trowbridge) – This topic introduces students to the catalytic processes that are routinely used for the stereoselective synthesis of target molecules.   New topic to be confirmed  (J. Abbenseth) –   Main Group Reagents in Synthesis (A.C. Regan) – This topic introduces students to the use of silicon-, sulfur- selenium- and phosphorus-containing reagents in organic synthesis. Metal-Organic Frameworks (Y. Ma) - This topic introduces students to porous metal-organic framework materials. Chemical Concepts from Quantum Mechanics (P. Popelier) – This topic introduces students to Quantum Chemical Topology, the most comprehensive and coherent way of extracting chemical insight from modern wavefunctions.The course will also introduce research-level topics in this area. <o:p></o:p></div> The over-arching aim of the personalised learning unit is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics, to provide a wider and deeper understanding of particular areas of chemistry. The key aims of each of the topics are: Contemporary f-Element Chemistry (D. Mills) – This topic introduces students to the use of molecular design to achieve landmark advances in non-aqueous f-element synthetic chemistry. Catalytic Asymmetric Synthesis (A. Trowbridge) – This topic introduces students to the catalytic processes that are routinely used for the stereoselective synthesis of target molecules.   New topic to be confirmed  (J. Abbenseth) –   Main Group Reagents in Synthesis (A.C. Regan) – This topic introduces students to the use of silicon-, sulfur- selenium- and phosphorus-containing reagents in organic synthesis. Metal-Organic Frameworks (Y. Ma) - This topic introduces students to porous metal-organic framework materials. Chemical Concepts from Quantum Mechanics (P. Popelier) – This topic introduces students to Quantum Chemical Topology, the most comprehensive and coherent way of extracting chemical insight from modern wavefunctions.The course will also introduce research-level topics in this area.  <div class="OutlineElement Ltr SCXW232392082 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;">On successful completion of the course students should be able to: <o:p></o:p>Contemporary f-Element Chemistry (D. Mills)ILO1 – Apply knowledge of f-element coordination/organometallic chemistry to create synthetic routes to complexes with designer geometries, coordination numbers and bonding regimes.  ILO2 – Interpret a range of experimental data to rationalise physicochemical properties and to propose f-element complex formulations and formal oxidation states at metal and ligand sites.  ILO3 – Apply knowledge of metal coordination spheres and redox chemistry to generate synthetic routes to f-element complexes with low and high formal metal oxidation states.  ILO4 – Predict and explain the outcomes of small molecule activation reactions of f-element complexes by consideration of experimental data, ligand effects, covalency and redox chemistry.  ILO5 – Classify f-element complexes containing redox non-innocent ligands and appraise data to interpret or to hypothesise aspects of structure, bonding and reactivity.  ILO6 – Compare and contrast lanthanide- and actinide-ligand multiple bonding regimes in order to rationalise relative complex stabilities and their reactivity profiles. Catalytic Asymmetric Synthesis (A. Trowbridge)  ILO1 – Interpret reactions commonly used in catalytic asymmetric synthesis.ILO2 - Predict the outcomes of unseen catalytic asymmetric reactions based on theoretical models.ILO3 – Develop strategies for the synthesis of unseen molecules using catalytic, asymmetric transformations. New topic to be confirmed (J. Abbenseth) ILO1 -  ILO2 –  ILO3 –  ILO4 –   Main Group Reagents in Synthesis (A.C. Regan)  ILO1 – describe the effects of heteroatoms on the reactivity of organic molecules containing them.ILO2 – explain how the presence of a heteroatom modifies the reactivity of an organic compound containing it.ILO3 – deduce the structure of appropriate heteroatom-containing reagents required to achieve given transformations.ILO4 – deduce the structure of products formed from organic reactions involving given heteroatom-containing reagents.ILO5 – write curly-arrow mechanisms for reactions involving heteroatom-containing organic reagents.  Metal-Organic Frameworks (Y. Ma)  ILO1 - Revision of metal-ligand coordination chemistry and explore their application in the assembly of extended “infinite” framework structures. Understand the concept of coordination geometry for multiple nuclear metal clusters and analysis of structural connectivity.ILO2 – Introduction of new advanced characterisation techniques for solid materials. Explore neutron scattering and understand the key Problem solving, analytical skills, time management.  <div style="border:1.0pt solid windowtext;mso-border-alt:solid windowtext .5pt;mso-element:para-border-div;padding:1.0pt 6.0pt 1.0pt 4.0pt;">Contemporary f-Element Chemistry (D. Mills)1. Synthetic routes to designer f-element complex geometries and coordination numbers.2. Experimental determination of oxidation state and covalency in f-element complexes.3. Achieving the lowest and highest f-element oxidation states.4. Small molecule activation reactions of f-element complexes.5. f-Element complexes of redox non-innocent ligands, including arenes.6. f-Element metal-ligand multiple bonding. Catalytic Asymmetric Synthesis (A. Trowbridge)  1) Principles of asymmetric synthesis2) Catalytic asymmetric 1,2-C=O bond addition3) Enamine catalysis and HPESW reaction4) Iminium and chiral acid catalysis5) TM-catalyzed asymmetric C=C bond hydrogenation6) Catalytic asymmetric C=O bond reduction7) Catalytic asymmetric alkene epoxidation8) Catalytic asymmetric alkene dihydroxylation   New topic to be confirmed (J. Abbenseth)This topic will cover... Main Group Reagents in Synthesis (A.C. Regan)  Properties of bonds to silicon; effects of silicon on charges.Silicon-oxygen bonds: protecting groups, trapping reagents, silyl enol ethers.Formation and reactions of vinyl silanesFormation and reactions of allyl silanesFormation and reactions of anions stabilised by silicon.Formation and reactions of carbanions stabilised by sulphur: the Julia alkene synthesis.Dithians, sulfoxides and sulfones.Formation and reactions of sulfur ylids.Reactions of allyl sulfoxides: [2,3]-sigmatropic rearrangements.Reactions of electrophilic sulfur and selenium reagents.The Pummerer rearrangement.Phosphorus-containing reagents: the Wittig reactionStereoselctivity in the Wittig reactionUse of phosphonate anions. Metal-Organic Frameworks (Y. Ma)  <ol><li>Introduction to metal-organic frameworks</li><li>General synthetic methods of metal-organic frameworks</li><li>Characterisation of metal-organic frameworks</li><li>Gas adsorption in metal-organic frameworks Chemical Concepts from Quantum </li></ol>Chemical Concepts from Quantum Mechanics (P. Popelier)The electron density and its LaplacianThe quantum atom and its properties (charge, energy, dipole moment,..)The mathematical language of dynamical systemEnergy partitioning scheme (“Interacting Quantum Atoms”, IQA)Characterisation of chemical bondingElectron Distribution Function (EDF)Electron Localisation Function (ELF)Electron Localisation-Delocalisation Matrices (LDMs) <o:p></o:p></div> 1 Written exam 100% <div><div style="border:1.0pt solid windowtext;mso-border-alt:solid windowtext .5pt;mso-element:para-border-div;padding:1.0pt 6.0pt 1.0pt 4.0pt;">Lecturing staff will provide office hours during the courseAfter the exam marking has been completed, students are provided with feedback <o:p></o:p></div></div> Pre-requisite units: Core chemistry  N <div><div><div style="border:1.0pt solid windowtext;mso-border-alt:solid windowtext .5pt;mso-element:para-border-div;padding:1.0pt 6.0pt 1.0pt 4.0pt;">Specific reading material will be provided separately for each topic.<o:p></o:p></div></div> </div>  Assessment written exam 2 eAssessment 5 Lectures 8 Supervised time in studio/wksp 8 Work based learning 12 0 65