Personalised Learning Unit 1

CHEM40111 Personalised Learning Unit 1 10 Semester 1 Undergraduate Level 4 Alan Brisdon Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 5.0 <div class="OutlineElement Ltr SCXW78103217 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;"><p class="Paragraph SCXW78103217 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-color:transparent;border-left:0.666667px solid rgb(0, 0, 0);border-right:0.666667px solid rgb(0, 0, 0);border-top:0.666667px solid rgb(0, 0, 0);color:windowtext;font-kerning:none;font-style:normal;font-weight:normal;margin:2px 0px 0px;overflow-wrap:break-word;padding:1.33333px 8px 1.33333px 5.33333px;text-align:left;text-indent:0px;user-select:text;vertical-align:baseline;white-space:pre-wrap;" data-ccp-border-bottom="0.6666666666666666px solid #000000" data-ccp-padding-bottom="1.3333333333333333px" paraid="77541835" paraeid="{3debee4c-fc30-4b35-badc-f84a1a907b40}{127}"><span class="EOP SCXW78103217 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-ccp-props="{"335572071":4,"335572072":1,"335572073":4278190080,"335572075":4,"335572076":6,"335572077":4278190080,"335572079":4,"335572080":1,"335572081":4278190080,"335572083":4,"335572084":4,"335572085":4278190080,"469789798":"single","469789802":"single","469789806":"single","469789810":"single"}"> </div><div class="OutlineElement Ltr SCXW78103217 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;"><p class="Paragraph SCXW78103217 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-color:transparent;border-left:0.666667px solid rgb(0, 0, 0);border-right:0.666667px solid rgb(0, 0, 0);color:windowtext;font-kerning:none;font-style:normal;font-weight:normal;margin:0px;overflow-wrap:break-word;padding:1.33333px 8px 1.33333px 5.33333px;text-align:left;text-indent:0px;user-select:text;vertical-align:baseline;white-space:pre-wrap;" data-ccp-border-top="0.6666666666666666px solid #000000" data-ccp-padding-top="1.3333333333333333px" data-ccp-border-bottom="0.6666666666666666px solid #000000" data-ccp-padding-bottom="1.3333333333333333px" paraid="2047529665" paraeid="{3debee4c-fc30-4b35-badc-f84a1a907b40}{131}">Contemporary Enzymology (S. Hay, A. Green) Advanced enzyme kinetics and analysis Study of enzyme mechanism using computational chemistry Study of enzyme mechanism using site directed mutagenesis and QSAR analysis Use of transition state analogues in enzymology and the design of catalytic antibodies Computational enzyme design Directed evolution to optimise enzymes Generating enzymes with non-natural catalytic amino acidsKinetics in Catalysis (J. Bures) Concepts of Chemical Kinetics (elasticity coefficient, rate laws of elementary and complex reactions). Concepts of Catalysis (catalyst, TON & TOF, rate-determining step, catalyst resting state, principle of detailed balance) Rate Laws for Catalytic Cycles (power-law, quasi-equilibrium assumption, Bodenstein steady-state approximation, King-Altman method, out-cycle catalytic species, saturation kinetics) Visual Kinetic Analyses: RPKA and VTNA (classic kinetic analyses, integral and differential methods, RPKA, VTNA, case studies) Modelling of Catalytic Reaction Kinetics (modelling methods, COPASI: model creation, basic plotting, time course simulation, parameter scan)Molecular Machines (G. de Bo) Principles governing the operation of molecular machines Design and synthesis of molecular switches, motors and other machines Chemical topologyRadiation Science (F. Currell, A. Baidak) Physics of primary radiation-induced processes; sources/generation of ionising radiation; Compton scattering, pair production, photoelectric effect; mass and mass energy-transfer attenuation coefficients; Stopping power; Linear Energy Transfer (LET); absorbed dose; ions vs gamma rays; G-value; water radiolysis; critical distance; escape probability; scavengers; radiation as maker; radiation as destroyer; radiation and health (radiotherapy).Synthetic Biology (R. Breitling, E. Takano) Central dogma of molecular biology Concepts of SynBio and DBTL cycle Key methods of industrial biotechnology (e.g., molecular biology and recombinant protein expression; DNA synthesis methods; State-of-art gene and genome assembly; directed enzyme evolution; modern DNA sequencing methods; metabolomics and transcriptome profiling; metabolic modelling; chassis engineering; and/ or molecular profile analysis) Modern applications of synbio (e.g., biofuels, high-value chemicals, materials; iGEM and Biobricks – the cutting-edge of SynBio) Social responsibility and ethical considerations for emerging technologies, sustainability, business prospects and considerationsGlycobiology (SL Flitsch) A short overview of the chemistry of carbohydrates Advanced chemical methods for carbohydrate synthesis Towards automated carbohydrate synthesis Structure determination of carbohydrates Enzymatic synthesis of carbohydrates A few key applications of carbohydrate chemistry in biology and medicineInorganic applications of density functional theory (N. Kaltsoyannis) What is density functional theory? Examples of the application of density functional theory to modern research problems: the 32 electron rule water complexes of Sr2+ creating new bonds by squeezing molecules very unusual radicals the reactivity of CO2 on MgO uranium-nitrogen multiple bonding an unusual case of structure-directing f orbitals</div> <div class="OutlineElement Ltr SCXW200763579 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;"><p class="Paragraph SCXW200763579 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-color:transparent;border-left:0.666667px solid rgb(0, 0, 0);border-right:0.666667px solid rgb(0, 0, 0);border-top:0.666667px solid rgb(0, 0, 0);color:windowtext;font-kerning:none;font-style:normal;font-weight:normal;margin:2px 0px 0px;overflow-wrap:break-word;padding:1.33333px 8px 1.33333px 5.33333px;text-align:left;text-indent:0px;user-select:text;vertical-align:baseline;white-space:pre-wrap;" data-ccp-border-bottom="0.6666666666666666px solid #000000" data-ccp-padding-bottom="1.3333333333333333px" paraid="109432452" paraeid="{4eff2f11-e4fa-4075-b889-0619cdb10112}{224}"><span class="TextRun SCXW200763579 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">The over-arching aims of these modules is to prepare students for a professional or research career in Chemistry by expanding core chemistry knowledge into advanced, research-based topics to provide a wider and deeper understanding of <span class="TextRun SCXW200763579 BCX8 NormalTextRun AdvancedProofingIssueV2Themed" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-image:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxMCIgaGVpZ2h0PSIyIj48ZyBmaWxsPSJub25lIiBmaWxsLXJ1bGU9ImV2ZW5vZGQiPjxwYXRoIGQ9Ik0wIDBoMTB2MkgweiIvPjxwYXRoIHN0cm9rZT0iI0FEQTJGMiIgc3Ryb2tlLWxpbmVjYXA9InJvdW5kIiBzdHJva2Utd2lkdGg9IjIiIGQ9Ik0xIDFoNCIvPjwvZz48L3N2Zz4=");background-position:0px 100%;background-repeat:repeat-x;border-bottom:1px solid transparent;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">particular areas<span class="TextRun SCXW200763579 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB"> of chemistry.<span class="EOP SCXW200763579 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-ccp-props="{"335572071":4,"335572072":1,"335572073":4278190080,"335572075 On successful completion of the course students should be able to:Extend ideas from core chemistry units from years 1, 2 and 3 to advanced topics Describe and explain the concepts and application of each topic Apply the concepts of the topic and extend these to synthesise new solutions Rationalise and interpret data from each topic Propose, and illustrate, outcomes of unseen extensions to the topic material <div>Problem solving, analytical skills, time management.</div>  <div class="OutlineElement Ltr SCXW237102054 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 255);clear:both;color:rgb(0, 0, 0);cursor:text;direction:ltr;font-family:"Segoe UI", "Segoe UI Web", Arial, Verdana, sans-serif;font-size:12px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin:0px;orphans:2;overflow:visible;padding:0px;position:relative;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:normal;widows:2;word-spacing:0px;"><p class="Paragraph SCXW237102054 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;background-color:transparent;border-left:0.666667px solid rgb(0, 0, 0);border-right:0.666667px solid rgb(0, 0, 0);color:windowtext;font-kerning:none;font-style:normal;font-weight:normal;margin:0px;overflow-wrap:break-word;padding:1.33333px 8px 1.33333px 5.33333px;text-align:left;text-indent:0px;user-select:text;vertical-align:baseline;white-space:pre-wrap;" data-ccp-border-top="0.6666666666666666px solid #000000" data-ccp-padding-top="1.3333333333333333px" data-ccp-border-bottom="0.6666666666666666px solid #000000" data-ccp-padding-bottom="1.3333333333333333px" paraid="1568896330" paraeid="{3debee4c-fc30-4b35-badc-f84a1a907b40}{209}"><span class="TextRun SCXW237102054 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">Contemporary Enzymology (<span class="TextRun SCXW237102054 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">S. Hay, A. Green<span class="TextRun SCXW237102054 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-ligatures:none !important;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">)<span class="EOP SCXW237102054 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;line-height:18.3458px;margin:0px;padding:0px;user-select:text;" data-ccp-props="{"335572071":4,"335572072":1,"335572073":4278190080,"335572075":4,"335572076":6,"335572077":4278190080,"335572079":4,"335572080":1,"335572081":4278190080,"335572083":4,"335572084":4,"335572085":4278190080,"469789798":"single","469789802":"single","469789806":"single","469789810":"single"}"> </div><div class="OutlineElement Ltr SCXW237102054 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;background-color:rgb(255, 255, 1 Written exam 100% Each segment of the course will provide a minimum of 1 workshop/example class. Lecturing staff will provide Office Hours during the course After the exam marking is completed, students are able to view their examination scripts. CHEM10101 Introductory Chemistry Pre-Requisite Compulsory CHEM10212 Energy and Change Pre-Requisite Compulsory CHEM10312 Coordination Chemistry Pre-Requisite Compulsory CHEM10412 Structure and Reactivity Pre-Requisite Compulsory CHEM20311 Group Theory: Fundamentals and Applications Pre-Requisite Compulsory CHEM20312 Inorganic Chemistry Pre-Requisite Compulsory CHEM20412 Structure and reactivity of organic molecules Pre-Requisite Compulsory CHEM20611 Spectroscopy Pre-Requisite Compulsory CHEM30211 Core Chemistry 3 Pre-Requisite Compulsory CHEM30311 Core Chemistry 2 Pre-Requisite Compulsory CHEM30312 Core Chemistry 4 Pre-Requisite Compulsory CHEM30411 Core Chemistry 1 Pre-Requisite Compulsory CHEM20212 Core Physical Chemistry Pre-Requisite Compulsory CHEM20411 Organic Synthesis Pre-Requisite Compulsory N Specific reading material, including research articles will be provided separately for each segment. Assessment written exam 1.5 Lectures 21 Practical classes & workshops 3 0 74.5