Advanced Chemistry Topics

CHEM60112 Advanced Chemistry Topics 15 Semester 2 Postgraduate Taught Level 6 Andrew Regan Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 7.5 The over-arching aim of the personalised learning unit is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics, to provide a wider and deeper understanding of particular areas of chemistry. The key aims of each of the topics are: Contemporary f-Element Chemistry (D. Mills) – This topic introduces students to the use of molecular design to achieve landmark advances in non-aqueous f-element synthetic chemistry. Catalytic Asymmetric Synthesis (A. Trowbridge) – This topic introduces students to the catalytic processes that are routinely used for the stereoselective synthesis of target molecules.   New topic to be confirmed  (J. Abbenseth) –   Main Group Reagents in Synthesis (A.C. Regan) – This topic introduces students to the use of silicon-, sulfur- selenium- and phosphorus-containing reagents in organic synthesis. Metal-Organic Frameworks (Y. Ma) - This topic introduces students to porous metal-organic framework materials. Chemical Concepts from Quantum Mechanics (P. Popelier) – This topic introduces students to Quantum Chemical Topology, the most comprehensive and coherent way of extracting chemical insight from modern wavefunctions.The course will also introduce research-level topics in this area.  The over-arching aim of the personalised learning unit is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics, to provide a wider and deeper understanding of particular areas of chemistry. The key aims of each of the topics are: Contemporary f-Element Chemistry (D. Mills) – This topic introduces students to the use of molecular design to achieve landmark advances in non-aqueous f-element synthetic chemistry. Catalytic Asymmetric Synthesis (A. Trowbridge) – This topic introduces students to the catalytic processes that are routinely used for the stereoselective synthesis of target molecules.   New topic to be confirmed  (J. Abbenseth) –   Main Group Reagents in Synthesis (A.C. Regan) – This topic introduces students to the use of silicon-, sulfur- selenium- and phosphorus-containing reagents in organic synthesis. Metal-Organic Frameworks (Y. Ma) - This topic introduces students to porous metal-organic framework materials. Chemical Concepts from Quantum Mechanics (P. Popelier) – This topic introduces students to Quantum Chemical Topology, the most comprehensive and coherent way of extracting chemical insight from modern wavefunctions.The course will also introduce research-level topics in this area.     The over-arching aim of this module is to prepare students for a professional career in Chemistry by expanding core chemistry knowledge into advanced topics to provide a wider and deeper understanding of particular areas of chemistry. <span class="TextRun SCXW9933502 BCX8 NormalTextRun" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-variant-caps:normal;font-variant-ligatures:none !important;font-weight:400;letter-spacing:normal;line-height:17.2667px;margin:0px;orphans:2;padding:0px;text-align:left;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:pre-wrap;widows:2;word-spacing:0px;" data-contrast="none" xml:lang="EN-GB" lang="EN-GB">On successful completion of the course students should be able to: <span class="EOP SCXW9933502 BCX8" style="-webkit-tap-highlight-color:transparent;-webkit-text-stroke-width:0px;-webkit-user-drag:none;font-family:"Microsoft Sans Serif", "Microsoft Sans Serif_EmbeddedFont", "Microsoft Sans Serif_MSFontService", sans-serif;font-size:11pt;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;line-height:17.2667px;margin:0px;orphans:2;padding:0px;text-align:left;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;user-select:text;white-space:pre-wrap;widows:2;word-spacing:0px;" data-ccp-props="{}"> Contemporary f-Element Chemistry (D. Mills)ILO1 – Apply knowledge of f-element coordination/organometallic chemistry to create synthetic routes to complexes with designer geometries, coordination numbers and bonding regimes.  ILO2 – Interpret a range of experimental data to rationalise physicochemical properties and to propose f-element complex formulations and formal oxidation states at metal and ligand sites.  ILO3 – Apply knowledge of metal coordination spheres and redox chemistry to generate synthetic routes to f-element complexes with low and high formal metal oxidation states.  ILO4 – Predict and explain the outcomes of small molecule activation reactions of f-element complexes by consideration of experimental data, ligand effects, covalency and redox chemistry.  ILO5 – Classify f-element complexes containing redox non-innocent ligands and appraise data to interpret or to hypothesise aspects of structure, bonding and reactivity.  ILO6 – Compare and contrast lanthanide- and actinide-ligand multiple bonding regimes in order to rationalise relative complex stabilities and their reactivity profiles. Catalytic Asymmetric Synthesis (A. Trowbridge)  ILO1 – Interpret reactions commonly used in catalytic asymmetric synthesis.ILO2 - Predict the outcomes of unseen catalytic asymmetric reactions based on theoretical models.ILO3 – Develop strategies for the synthesis of unseen molecules using catalytic, asymmetric transformations. New topic to be confirmed (J. Abbenseth) ILO1 -  ILO2 –  ILO3 –  ILO4 –   Main Group Reagents in Synthesis (A.C. Regan)  ILO1 – describe the effects of heteroatoms on the reactivity of organic molecules containing them.ILO2 – explain how the presence of a heteroatom modifies the reactivity of an organic compound containing it.ILO3 – deduce the structure of appropriate heteroatom-containing reagents required to achieve given transformations.ILO4 – deduce the structure of products formed from organic reactions involving given heteroatom-containing reagents.ILO5 – write curly-arrow mechanisms for reactions i <div> Problem solving, analytical skills, time management. </div>  Students choose 4 of these:Contemporary f-Element Chemistry (D. Mills)  General coordination chemistry and oxidation states Achieving the highest oxidation states Achieving the lowest oxidation states Redox non-innocent ligands and arenes Small molecule activation reactions Metal-ligand multiple bondingMetal organic Frameworks, MOFs (Y. Ma) Synthesis of MOFs Characterisation of MOFs  Applications of MOFsInorganic Computational Chemistry (H. Morgan)  Catalytic Asymmetric Synthesis (A. Trowbridge)  Principles of asymmetric synthesis; Asymmetric hydrogenation of alkenes and ketones; Asymmetric  epoxidation: i. allylic alcohols, ii. unfunctionalised alkenes, iii. synthetic applications of epoxides; Asymmetric C-C bond forming reactions: i. Aldol reactions, ii. Michael reactions, iii. Asymmetric cycloaddition reactions.  Biological perspectives.Main Group Reagents in Synthesis (A.C. Regan)  Properties of bonds to silicon; effects of silicon on charges. Silicon-oxygen bonds: protecting groups, trapping reagents, silyl enol ethers. Formation and reactions of vinyl silanes Formation and reactions of allyl silanes Formation and reactions of anions stabilised by silicon. Formation and reactions of carbanions stabilised by sulphur: dithianes, sulfoxides and sulfones. Formation and reactions of sulfur ylids. Reactions of allyl sulfoxides: [2,3]-sigmatropic rearrangements. Reactions of electrophilic sulfur and selenium reagents. The Pummerer rearrangement. Hydroboration reactions. Reactions of allyl boranes and boronates.Quantum Chemistry (P. Popelier, J. Skelton) Generalisation of the quantum harmonic oscillator (QHO) model of vibrations to polyatomic systems and its extension to phonons in periodic solids Key concepts in the lattice dynamics of solids: the phonon Brillouin zone, wave vectors, the phonon dispersion and density of states, and acoustic and optic modes Relationship between the phonon spectrum and thermodynamic functions, and the use of statistical thermodynamics to predict material properties Relationship between imaginary harmonic modes, the potential-energy surface (PES), and “soft-mode” phase transitions Predicting the infrared activity of vibrations   1 Written exam 100% <div> Lecturing staff will provide office hours during the courseAfter the exam marking has been completed, students are provided with feedback  </div>  MSc Chemistry MSc Chemistry PGDT Taught Component Mandatory N Specific reading material will be provided separately for each topic.  Assessment written exam 3 Lectures 28 Practical classes & workshops 12 0 0