Advanced Analytical Chemistry

CHEM30222 Advanced Analytical Chemistry 10 Semester 2 Undergraduate Level 6 Lars Nilsson Unit coordinator Department of Chemistry 1 FHEQ level (Framework for Higher Education Qualifications) ' Last part of a Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 This unit allows students to study three segments of research-informed advanced analytical chemistry topics.   This unit allows students to study three segments of research-informed advanced analytical chemistry topics.   The over-arching aims of these modules is to prepare students for a professional or research career in Chemistry by expanding core chemistry knowledge into advanced, research-based topics in analytical chemistry.The key aims of each of the segments are:  Advanced NMR - introduce students to a range of advanced NMR methods and their applications to problems in chemistry, biochemistry and medicine.Mass Spectrometry of Biological Systems – introduces students to the application of mass spectrometry to real-world examples from health and structural biology.Surface Analysis - introduces students to the fundamentals of surface science and the techniques used to gain atomic-scale understanding of surface chemistry.  On successful completion of the course students should be able to:  <ul><li>Extend ideas from core chemistry units from years 1, 2 and 3 to advanced topics.</li><li>Describe and explain the concepts and application of each analytical method.</li><li>Apply the concepts of the topics and extend these to synthesise new understanding.</li><li>Rationalise and interpret data from each analytical method.</li><li>Propose, and illustrate, outcomes of unseen extensions to the topic material.</li></ul> Problem solving, analytical skills, time management.  Advanced NMR (G.A. Morris, M. Nilsson)<ul><li>Pulsed field gradients and pulsed field gradient stimulated echo experiments.</li><li>Spatial encoding and diffusional attenuation.</li><li>Diffusion-ordered spectroscopy (DOSY).</li><li>Qualitative and quantitative information from NMR diffusion experiments.</li><li>Methods for studying the 3D structures and dynamics of biomolecules.</li><li>Applications of NMR spectroscopy to living systems.</li></ul>Mass Spectrometry of Biological Systems (P. Barran)<ul><li>Basics of mass spectrometry and how it is applied to  biological analysis.</li><li>Components of a mass spectrometer and how it can be used to separate and identify compounds.</li><li>Common methods of ionisation and to highlight choice of ionisation to suit the compound(s) to be analysed.</li><li>Hyphenation of mass spectrometry with chromatography.</li><li>The application of mass spectrometry to study metabolites, lipds and proteins (bottom up analysis).</li><li>The use of mass spectrometry data to identify and quantify biomolecules and hence to understand biological processes.</li><li>Native mass spectrometry. </li><li>Real world examples from health and structural biology.</li></ul>Surface Analysis (A. Walton)<ul><li>UHV technology and monolayer formation times. </li><li>Surfaces and reconstructions. </li><li>X-Ray Photoelectron Spectroscopy. </li><li>Secondary Ion Mass Spectrometry. </li><li>Scanning Probe Microscopy. </li><li>Low Energy Electron Diffraction. </li><li>Frontiers of surface science (in-situ methodologies). </li></ul> 1 Written exam 100% Each segment of the course will provide a minimum of 1 workshop/example class. Lecturing staff will provide Office Hours during the course.After the exam marking is completed, students are able to view their examination scripts.  CHEM10101 Introductory Chemistry Pre-Requisite Compulsory CHEM10212 Energy and Change Pre-Requisite Compulsory CHEM10312 Coordination Chemistry Pre-Requisite Compulsory CHEM10412 Structure and Reactivity Pre-Requisite Compulsory CHEM20311 Group Theory: Fundamentals and Applications Pre-Requisite Compulsory CHEM20312 Inorganic Chemistry Pre-Requisite Compulsory CHEM20412 Structure and reactivity of organic molecules Pre-Requisite Compulsory CHEM20611 Spectroscopy Pre-Requisite Compulsory CHEM30211 Core Chemistry 3 Pre-Requisite Compulsory CHEM30411 Core Chemistry 1 Pre-Requisite Compulsory CHEM20212 Core Physical Chemistry Pre-Requisite Compulsory CHEM20411 Organic Synthesis Pre-Requisite Compulsory N Specific reading material, including research articles will be provided separately for each segment.  Lectures 21 Practical classes & workshops 3 0 76