MATS23801
Biomaterials & Biological Interactions
10
Semester 1
Undergraduate
Level 5
Alison Harvey
Unit coordinator
Department of Materials
1
FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors '
European Credit Transfer & Accumulation System Rating : 5.0
<p>This unit introduces the basic principles of cell biology to explain how cells interact with different materials based on their physicochemical properties. The understanding of the ways biological tissues interact with materials will be advanced by examining the concepts of immunological response, haemocompatibility, toxicology and ultimately biocompatibility. The unit investigates how we can study cell behaviour with the ultimate goal the engineering of biomaterials that will control and instruct cell responses. </p><p> </p>
<p>This unit introduces the basic principles of cell biology to explain how cells interact with different materials based on their physicochemical properties. The understanding of the ways biological tissues interact with materials will be advanced by examining the concepts of immunological response, haemocompatibility, toxicology and ultimately biocompatibility. The unit investigates how we can study cell behaviour with the ultimate goal the engineering of biomaterials that will control and instruct cell responses. </p><p>Topics covered include:</p><ul> <li>Key components of cells and tissues of relevance to biomaterials. </li> <li>The body’s immune responses, and how the immune system can interact with biomaterials.</li> <li>The inflammatory response and how this can be triggered by implanted materials. </li> <li>How cells interact with different materials based on a variety of material properties.</li> <li>The factors controlling toxicology and the body’s response. </li> <li>Tissue interactions with materials (both local and at the systemic level).</li> <li>Understanding the concept of biocompatibility.</li> <li>How we can engineer materials to control cell responses.</li></ul>
<p>The unit aims to: </p><ul> <li> Develop the theoretical and practical principles required to understand biomaterials in the body. </li> <li> Understand how we can engineer materials to control cell responses. </li> <li> Develop an understanding of biocompatibility.</li></ul><p> </p>
<p>A greater depth of the learning outcomes will be covered in the following sections:</p>
<ul>
<li>
Knowledge and understanding</li>
<li>
Intellectual skills</li>
<li>
Practical skills</li>
<li>
Transferable skills and personal qualities</li>
</ul>
<div> •<span style="white-space:pre"> </span>Demonstrate an understanding of the key components of cells and tissues that are of relevance to biomaterials. </div><div> •<span style="white-space:pre"> </span>Demonstrate knowledge of the basic patho-physiological responses of the body relevant to biomaterials such as immune responses, inflammation, and toxicity. </div><div> •<span style="white-space:pre"> </span>Demonstrate an understanding of how the patho-physiological responses of the body are triggered by implanted materials. </div><div> •<span style="white-space:pre"> </span>Demonstrate knowledge of the range of factors that influence cell responses for a material. </div><div> •<span style="white-space:pre"> </span>Demonstrate an understanding of how materials physical properties (strength, stiffness etc) alter the cell response. </div><div> •<span style="white-space:pre"> </span>Demonstrate an understanding of how to manipulate these properties to control cell responses. </div><div> •<span style="white-space:pre"> </span>Demonstrate an understanding of the main types of tissue interactions with biomaterials, on a local and systemic level.</div><div> •<span style="white-space:pre"> </span>Understand the concept of biocompatibility. </div><div> •<span style="white-space:pre"> </span>Demonstrate a basic knowledge of some key applications of biomaterials.</div><div> </div>
<div> <div> •<span style="white-space:pre"> </span>Show knowledge of the various processes of the body that are involved in biocompatibility. </div> <div> •<span style="white-space:pre"> </span>Demonstrate an understanding of the effect of changing the chemical and physical properties of materials on cell behaviour.</div> <div> </div></div><p> </p>
<div>• Develop awareness of practical aspects associated with experimental design.<br />• Perform cell-material interaction studies. <br />• Record and analyse data from cell culture experiments.<br />• Analyse data from cell culture experiments.<br /> </div>
<div> •<span style="white-space:pre"> </span>Work effectively in a group to solve problems. </div><div> •<span style="white-space:pre"> </span>Compose simple technical reports on laboratory tests. </div><div> •<span style="white-space:pre"> </span>Ability to analyse and discuss experimental procedures and results.</div><div> </div>
<p>This unit takes a blended learning approach. Following each in person lecture you should work through the online content before the next lecture. Canvas quizzes in weeks 3, 5, and 9 count towards coursework and will rely on you being up to date with the online content.</p>
1
Written exam
70%
2
Written assignment (inc essay)
15%
9
Set exercise
15%
<p>Verbal and written</p>
N
<ul> <li> Biomaterials Science, 2<sup>nd</sup> or 3<sup>rd</sup> Edition, Ratner, Elsevier Academic Press.</li> <li> Biochemistry: Berg, Tymoczko and Stryer ‘Biochemistry’ (ISBN: 0-7176-4684-0) I will use the 5<sup>th</sup> Edition for teaching but earlier editions will be fine for you to work from too. </li> <li> Molecular Biology of The Cell: Alberts, Johnson, Lewis, Raff, Roberts and Walter (ISBN: 978-0-8/153-4106-2. I will use the 5<sup>th</sup> Edition for teaching but again, earlier editions will be fine too.</li></ul><p style="margin-left:18.0pt;">There are plenty of copies in the library and you can often pick up 2<sup>nd</sup> hand copies of these textbooks from local bookshops/sales. In addition ask Olga for pdf versions of the textbooks.</p><p> </p>
Lectures
20
0
80