MATS23801 10 Semester 1 Undergraduate Level 5 Alison Harvey Unit coordinator Department of Materials 1 FHEQ level (Framework for Higher Education Qualifications) ' Middle part of Bachelors ' European Credit Transfer & Accumulation System Rating : 5.0 <p>This unit introduces the basic principles of cell biology to explain how cells interact with different materials based on their physicochemical properties. The understanding of the ways biological tissues interact with materials will be advanced by examining the concepts of immunological response, haemocompatibility, toxicology and ultimately biocompatibility.&nbsp; The unit investigates how we can study cell behaviour with the ultimate goal the engineering of biomaterials that will control and instruct cell responses.</p> <p>This unit introduces the basic principles of cell biology to explain how cells interact with different materials based on their physicochemical properties. The understanding of the ways biological tissues interact with materials will be advanced by examining the concepts of immunological response, haemocompatibility, toxicology and ultimately biocompatibility.&nbsp; The unit investigates how we can study cell behaviour with the ultimate goal the engineering of biomaterials that will control and instruct cell responses.&nbsp;</p><p>Topics covered include:</p><ul> <li>Key components of cells and tissues of relevance to biomaterials.&nbsp;</li> <li>The body&rsquo;s immune responses, and how the immune system can interact with biomaterials.</li> <li>The inflammatory response and how this can be triggered by implanted materials.&nbsp;</li> <li>How cells interact with different materials based on a variety of material properties.</li> <li>The factors controlling toxicology and the body&rsquo;s response.&nbsp;</li> <li>Tissue interactions with materials (both local and at the systemic level).</li> <li>Understanding the concept of biocompatibility.</li> <li>How we can engineer materials to control cell responses.</li></ul> <p>The unit aims to:&nbsp;</p><ul><li>Develop the theoretical and practical principles required to understand biomaterials in the body.&nbsp;</li><li>Understand how we can engineer materials to control cell responses.&nbsp;</li><li>Develop an understanding of biocompatibility.</li></ul> <p>A greater depth of the learning outcomes will be covered in the following sections:</p> <ul> <li> Knowledge and understanding</li> <li> Intellectual skills</li> <li> Practical skills</li> <li> Transferable skills and personal qualities</li> </ul> <ul><li>Demonstrate an understanding of the key components of cells and tissues that are of relevance to biomaterials.&nbsp;</li><li>Demonstrate knowledge of the basic patho-physiological responses of the body relevant to biomaterials such as immune responses, inflammation, and toxicity.&nbsp;</li><li>Demonstrate an understanding of how the patho-physiological responses of the body are triggered by implanted materials.&nbsp;</li><li>Demonstrate knowledge of the range of factors that influence cell responses for a material.&nbsp;</li><li>Demonstrate an understanding of how materials physical properties (strength, stiffness etc) alter the cell response.&nbsp;</li><li>Demonstrate an understanding of how to manipulate these properties to control cell responses.&nbsp;</li><li>Demonstrate an understanding of the main types of tissue interactions with biomaterials, on a local and systemic level.</li><li>Understand the concept of biocompatibility.&nbsp;</li><li>Demonstrate a basic knowledge of some key applications of biomaterials&nbsp;</li></ul> <div><ul><li>Show knowledge of the various processes of the body that are involved in biocompatibility.&nbsp;</li><li>Demonstrate an understanding of the effect of changing the chemical and physical properties of materials on cell behaviour.</li></ul></div> <ul><li>Develop awareness of practical aspects associated with experimental design.</li><li>Perform cell-material interaction studies.&nbsp;</li><li>Record and analyse data from cell culture experiments.</li><li>Analyse data from cell culture experiments.</li></ul> <ul><li>Work effectively in a group to solve problems.&nbsp;</li><li>Compose simple technical reports on laboratory tests.&nbsp;</li><li>Ability to analyse and discuss experimental procedures and results.</li></ul> <p>Lectures, lab practical classes, recommended textbooks, web resources, past exam papers, electronic supporting information (Canvas), peer-assisted study sessions (PASS).</p><p>This unit is delivered using a blended learning approach, which integrates technology and digital media with traditional classroom activities. A variety of learning and teaching processes will be used including: lectures, discussions, group activities and independent study. Canvas will be used to present online study materials, including videos, lecture notes, guided reading, articles and other information. Canvas will also be used for the submission of assessments.</p> 1 Written exam 70% 2 Written assignment (inc essay) 15% 9 Set exercise 15% <p>Verbal and written</p> N <p>The recommended reading for this unit can be found on the <a href="https://www.readinglists.manchester.ac.uk/leganto/public/44MAN_INST/lists/338986348730001631?auth=CAS">online unit reading list</a>.</p> Lectures 20 0 80