Stem Cells, Transfusion and Solid Organ Transplantation

MEDN61042 Stem Cells, Transfusion and Solid Organ Transplantation 30 Semester 2 Postgraduate Taught Level 7 Stephine Whiteside Unit coordinator School of Medical Sciences 1 FHEQ level (Framework for Higher Education Qualifications) ' Masters/Integrated Masters P4 ' European Credit Transfer & Accumulation System Rating : 15.0 Indicative content of the Unit includes: • Immunopathogenesis of conditions for which haemopoietic stem cell transplantation is a suitable option. • Complex HSCT donor selection, stem cell processing and pharmaceutical considerations. • Monitoring and complications post-HSCT. • Advanced therapeutic medicinal products.  • Immunology of platelets and granulocytes related to transfusion products and clinical indications for their use. • Pathogenesis, investigation and risk reduction of transfusion-related adverse immunological events related to HLA, HPA and HNA. • Complex renal transplantation and associated complications. • Solid organ transplantation of organs other than the kidney. • Novel grafts and in vitro products • Ethical considerations related to donors and recipients of transplants.• For students on the NHS Scientist Training Programme, this Unit corresponds to S-HAI-S2 and S-HAI-S3 in the NSHCS Curriculum Library.   Indicative content of the Unit includes: • Immunopathogenesis of conditions for which haemopoietic stem cell transplantation is a suitable option. • Complex HSCT donor selection, stem cell processing and pharmaceutical considerations. • Monitoring and complications post-HSCT. • Advanced therapeutic medicinal products.  • Immunology of platelets and granulocytes related to transfusion products and clinical indications for their use. • Pathogenesis, investigation and risk reduction of transfusion-related adverse immunological events related to HLA, HPA and HNA. • Complex renal transplantation and associated complications. • Solid organ transplantation of organs other than the kidney. • Novel grafts and in vitro products • Ethical considerations related to donors and recipients of transplants.• For students on the NHS Scientist Training Programme, this Unit corresponds to S-HAI-S2 and S-HAI-S3 in the NSHCS Curriculum Library.   This Unit aims to provide you with an advanced understanding of haemopoietic stem cell transplantation, aspects of transfusion relevant to H&I, and complex aspects of solid organ transplantation.  You will develop knowledge of haemopoietic stem cell donation, testing, harvesting and post-transplant monitoring and how human leukocyte antigen (HLA) typing results are used in the context of matching recipients with suitable donors in a variety of clinical settings.  You will evaluate the involvement of H&I in relevant transfusion products, including platelets and granulocytes, including the clinical indications for their use.  You will further develop your understanding of complex solid organ transplantation, building on your knowledge of renal transplantation.  You will review the use of novel medicinal products that are under development and becoming available as an alternative to traditional solid organ and haemopoietic stem cell transplants. Finally, you will evaluate the myriad of ethical considerations that pertain to both the donor and recipient of the variety of transplant types that are available. 1. Discuss the pathogenesis of malignant and non-malignant indications for HSCT. 2. Explain the pre-conditioning therapies and post-transplant patient management associated with malignant and non-malignant indications for HSCT. 3. Describe the processes involved in the preparation of haemopoietic stem cells for HSCT. 4. Apply knowledge of the post-transplant monitoring of HSCT.  5. Describe the immunopathogenesis and management of complications associated with HSCT. 6. Explain the relevance of HLA, HPA, HNA and other antigens in the use of a variety of blood products. 7. Describe the adverse immunological events that can arise following transfusion of blood products and their investigation. 8. Discuss the indications for platelet transfusion and the causes of platelet refractoriness. 9. Describe the role of histocompatibility testing in pre-transplant work-up and post-transplant management of patients undergoing a variety of solid organ transplants. 10. Critically appraise the novel forms of transplantation in development. 11. Discuss the ethical considerations associated with transplantation. 1. Critically analyse scientific and clinical data 2. Present scientific and clinical data appropriately. 3. Formulate a critical argument 4. Evaluate scientific and clinical literature 5. Apply the knowledge of clinical immunology to address specific clinical problems 1. Present information clearly in the form of verbal and written reports. 2. Communicate complex ideas and arguments in a clear and concise and effective manner. 3. Work effectively as an individual or part of a team.  4. Use conventional and electronic resources to collect, select and organise complex scientific information 1. Present complex ideas in simple terms in both oral and written formats 2. Consistently operate within sphere of personal competence and level of authority. 3. Manage personal workload and objectives to achieve quality of care. 4. Actively seek accurate and validated information from all available sources. 5. Select and apply appropriate analysis or assessment techniques and tools. 6. Evaluate a wide range of data to assist with judgements and decision-making. 7. Interpret data and convert into knowledge for use in the clinical context of individual and groups of patients. 8. Work in partnership with colleagues to solve problems.   Seminars and workshops, supported by self-directed online learning materials including clinical case studies, audio lectures, discussion boards and recommended reading. 1 Written exam 49% 2 Written assignment (inc essay) 17% 7 Oral assessment/presentation 17% 9 Set exercise 17% Written feedback in accordance with T&L guidelines for 30-credit Units. MEDN61870 Fundamental Principles of Histocompatibility and Immunogenetics Pre-Requisite Compulsory N A reading list with recommended supporting texts will be provided via the University library’s ‘Reading Lists Online’  Lectures 300 0 0 Notional hours of learning: The number of hours which it is expected that a learner (at a particular level) will spend, on average, to achieve the specified learning outcomes at that level. It is expected that there will be 10 hours of notional study associated with every 1 credit achieved. Therefore if a unit is worth 30 credits, this will equate to 300 notional study hours, in accordance with the Credit Framework (QAA).